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Multiple late complications of therapy with cyclophosphamide, including ovarian destruction

Identifieur interne : 003B68 ( Main/Exploration ); précédent : 003B67; suivant : 003B69

Multiple late complications of therapy with cyclophosphamide, including ovarian destruction

Auteurs : John J. Miller Iii [États-Unis] ; Gordon F. Williams [États-Unis] ; John C. Leissring [États-Unis]

Source :

RBID : ISTEX:518838735219A1D81F42FD72C9255526B635A6DD

English descriptors

Abstract

Abstract: The sudden, late appearance of multiple complications and the autopsy demonstration of a newly recognized side effect, ovarian destruction, are described in a young girl treated for a prolonged period with cyclophosphamide. She suffered the nearly simultaneous appearance of Pneumocystis carinii pneumonia and severe urinary tract hemorrhage in the twenty-ninth month of therapy. At autopsy, the ovaries were found to be totally lacking in ova or follicles, although the child was known to have had a normal XX chromosomal constitution. We believe that the ovarian disease observed in this case is the lesion associated with the amenorrhea which has recently been reported to occur during prolonged cyclophosphamide therapy in adults.

Url:
DOI: 10.1016/0002-9343(71)90341-X


Affiliations:


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Le document en format XML

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<term>Blood cell count</term>
<term>Carinii</term>
<term>Chloroquine therapy</term>
<term>Cyciophosphamide therapy</term>
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<term>Eosin stain</term>
<term>Erythematosus</term>
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<term>Hemorrhagic cystitis</term>
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<term>Late appearance</term>
<term>Lmmunoglobulin levels</term>
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<term>Ovarian</term>
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<term>Rheumatoid arthritis</term>
<term>Salmonella antibodies</term>
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<div type="abstract" xml:lang="en">Abstract: The sudden, late appearance of multiple complications and the autopsy demonstration of a newly recognized side effect, ovarian destruction, are described in a young girl treated for a prolonged period with cyclophosphamide. She suffered the nearly simultaneous appearance of Pneumocystis carinii pneumonia and severe urinary tract hemorrhage in the twenty-ninth month of therapy. At autopsy, the ovaries were found to be totally lacking in ova or follicles, although the child was known to have had a normal XX chromosomal constitution. We believe that the ovarian disease observed in this case is the lesion associated with the amenorrhea which has recently been reported to occur during prolonged cyclophosphamide therapy in adults.</div>
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