Multiple late complications of therapy with cyclophosphamide, including ovarian destruction
Identifieur interne : 003B68 ( Main/Exploration ); précédent : 003B67; suivant : 003B69Multiple late complications of therapy with cyclophosphamide, including ovarian destruction
Auteurs : John J. Miller Iii [États-Unis] ; Gordon F. Williams [États-Unis] ; John C. Leissring [États-Unis]Source :
- The American Journal of Medicine [ 0002-9343 ] ; 1971.
English descriptors
- Teeft :
- American journal, Antibody production, Arthritis rheum, Autopsy, Basic disease, Blood cell count, Carinii, Chloroquine therapy, Cyciophosphamide therapy, Cyclophosphamide, Cyclophosphamide therapy, Eosin stain, Erythematosus, Follicle, Hemorrhagic cystitis, Immune system, Late appearance, Lmmunoglobulin levels, Lupus, Lymph nodes, Lymphocyte, Nephrotic syndrome, Normal levels, Original magnification, Ovarian, Ovarian pathology, Ovary, Pneumocystis, Pneumocystis carinii pneumonia, Positive lupus erythematosus cell tests, Prednisone, Prednisone dose, Recurrent myocarditis, Rheumatoid arthritis, Salmonella antibodies, Second course, Stromal cells, Systemic lupus erythematosus, Urinary tract, White blood cell count.
Abstract
Abstract: The sudden, late appearance of multiple complications and the autopsy demonstration of a newly recognized side effect, ovarian destruction, are described in a young girl treated for a prolonged period with cyclophosphamide. She suffered the nearly simultaneous appearance of Pneumocystis carinii pneumonia and severe urinary tract hemorrhage in the twenty-ninth month of therapy. At autopsy, the ovaries were found to be totally lacking in ova or follicles, although the child was known to have had a normal XX chromosomal constitution. We believe that the ovarian disease observed in this case is the lesion associated with the amenorrhea which has recently been reported to occur during prolonged cyclophosphamide therapy in adults.
Url:
DOI: 10.1016/0002-9343(71)90341-X
Affiliations:
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- to stream Main, to step Curation: 003B68
Le document en format XML
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<term>Cyciophosphamide therapy</term>
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<term>Cyclophosphamide therapy</term>
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<term>Erythematosus</term>
<term>Follicle</term>
<term>Hemorrhagic cystitis</term>
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<front><div type="abstract" xml:lang="en">Abstract: The sudden, late appearance of multiple complications and the autopsy demonstration of a newly recognized side effect, ovarian destruction, are described in a young girl treated for a prolonged period with cyclophosphamide. She suffered the nearly simultaneous appearance of Pneumocystis carinii pneumonia and severe urinary tract hemorrhage in the twenty-ninth month of therapy. At autopsy, the ovaries were found to be totally lacking in ova or follicles, although the child was known to have had a normal XX chromosomal constitution. We believe that the ovarian disease observed in this case is the lesion associated with the amenorrhea which has recently been reported to occur during prolonged cyclophosphamide therapy in adults.</div>
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